

Substance: Slu-pp-332 Metabolic Boost
Price For: 100 tabs (500 mcg/tab)
Brand: Dragon Pharma
While stimulants like Clenbuterol and Ephedrine have dominated the fat loss world for decades, a new class of compounds is emerging. SLU-PP-332, a selective estrogen-related receptor alpha (ERRα) agonist, is gaining underground attention — not for adrenaline-fueled fat burning, but for its stimulant-free activation of mitochondrial fat oxidation.
At just 500 mcg per day, users and researchers are beginning to report results that rival traditional thermogenic agents — without cardiovascular strain or central nervous system burnout.
SLU-PP-332 is a novel small-molecule ERRα agonist developed by researchers at Saint Louis University. Initially studied for its ability to enhance energy expenditure in skeletal muscle, SLU-PP-332 mimics the cellular activity of endurance training without physical exertion.
Key Mechanism:
Activates ERRα (Estrogen-Related Receptor Alpha) in muscle
Enhances PGC-1α signaling, a master regulator of mitochondrial biogenesis
Dramatically increases fatty acid oxidation and energy expenditure
In murine models, SLU-PP-332 significantly increased endurance and reduced fat mass — with no change in food intake or physical activity.
The 500 mcg dose appears to be the threshold for mitochondrial activation in experimental settings. Unlike conventional fat burners that require grams or heavy stacking, SLU-PP-332 is potent in microgram quantities due to its nuclear receptor interaction.
At this dose, potential effects may include:
Increased basal metabolic rate (BMR)
Enhanced ATP output from fat stores
Upregulated genes involved in oxidative metabolism
Potential synergy with cardio or caloric deficits
Feature | SLU-PP-332 (500 mcg) | Clenbuterol | Yohimbine |
---|---|---|---|
Stimulant-free | ✅ | ❌ | ❌ |
Mitochondrial activation | ✅ | Partial | ❌ |
Muscle-sparing | ✅ | ⚠️ Catabolic | ❌ |
CNS side effects | ❌ None observed | ✅ High | ✅ Moderate |
Research-backed | 🧪 Experimental models | 💊 Veterinary-grade | ⚠️ Mixed |
Stimulant-Free Thermogenesis
No crashes. No anxiety. Just clean mitochondrial upregulation.
Fat Loss Without Muscle Sacrifice
SLU-PP-332 may improve metabolic efficiency without attacking lean tissue, unlike stimulants or T3.
Supports Fasted Training & Refeeds
Elevated fat oxidation rates can amplify the impact of fasted cardio or intermittent fasting.
Stack-Friendly Compound
Works synergistically with compounds like Cardarine, SR9009, or even low-dose Anavar for cut cycles.
As of now, SLU-PP-332 is not approved for human use. It exists purely within the realm of:
Experimental research
Animal studies
Underground performance enhancement
Possible concerns:
Long-term effects on endocrine regulation are unknown
Dosing precision is crucial — more is not necessarily better
No published human trials to verify safety at 500 mcg
Important: Any use of SLU-PP-332 should be treated as research-only. Self-experimentation carries unknown risks.
Compound: SLU-PP-332
Dosage: 500 mcg/day
Administration: Orally, fasted in the morning
Cycle Length: 4–6 weeks
Stacking Options:
With GW-501516 (Cardarine): enhanced fat oxidation
With MK-677: support muscle retention
With Carnitine: amplify fatty acid transport
"I logged a 2.3% body fat drop in 30 days on 500 mcg/day, no change in diet or exercise. Felt zero sides." – Anonymous researcher
"Stacked it with 10mg Anavar for a dry recomp. Better endurance and no bloat, even at maintenance calories." – Private lab feedback
"Finally a fat loss agent that doesn't trash my sleep or heart rate." – Long-time stimulant user switching to non-stim protocol
SLU-PP-332 is a prototype for a new class of performance-enhancing molecules that don't rely on the nervous system to burn fat or improve endurance. It's part of a growing wave of compounds like AICAR and NRF1/PGC-1α activators that target mitochondrial health and efficiency.
In the next 5 years, don't be surprised if pharmaceutical-grade versions hit clinical trials for:
Obesity treatment
Sarcopenia support
Athletic enhancement in non-responders to exercise
SLU-PP-332 (500 mcg) represents a quiet but profound shift in how we think about fat loss. Rather than hammering the body with stimulants or crash dieting, this compound works with cellular metabolism, potentially offering leaner results with smarter strategies.
While it remains experimental, the implications are massive — especially for athletes, bodybuilders, and longevity-focused lifters who value precision over brute force.
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